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Apoptosis (2013) 18:1145?153 DOI ten.1007/s10495-013-0859-xORIGINAL PAPERThe anti-apoptotic effect of regucalcin is mediated through multisignaling pathwaysMasayoshi YamaguchiPublished on the web: 14 Might 2013 ?The Author(s) 2013. This short article is published with open access at SpringerlinkAbstract Regucalcin (RGN/SMP30) was originally discovered in 1978 as a calcium-binding protein that doesn’t contain the EF-hand motif of as a calcium-binding domain.Bis(triphenylphosphine)dichloronickel In stock The name, regucalcin, was proposed for this calciumbinding protein, which can regulate several Ca2?-dependent enzymes activation in liver cells.PMID:26760947 The regucalcin gene is localized on the X chromosome, and its expression is mediated via many signaling elements. Regucalcin plays a pivotal function in regulation of intracellular calcium homeostasis in a variety of cell types. Regucalcin also features a suppressive impact on different signaling pathways in the cytoplasm to nucleus in proliferating cells and regulates nuclear function in like deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) synthesis. Overexpression of endogenous regucalcin was located to suppress apoptosis in modeled rat hepatoma c.