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NIH Public AccessAuthor ManuscriptPediatr Nephrol. Author manuscript; obtainable in PMC 2014 November 01.Published in final edited form as: Pediatr Nephrol. 2013 November ; 28(11): 2179?188. doi:ten.1007/s00467-013-2524-6.NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author ManuscriptA Novel Urinary Biomarker Profile to Identify Acute Kidney Injury (AKI) in Critically Ill Neonates – A Pilot StudySuma Bhat Hoffman, MD1,*, An N.CataCXium A Pd G3 Data Sheet Massaro, MD1,three, gel A.4-Acryloylmorpholine manufacturer Soler-Garc , PhD2,**, Sofia Perazzo, PhD2, and Patricio E.PMID:24914310 Ray, MD2,1Neonatology, 2Children’sChildren’s National Medical Center, Washington, DC, United StatesResearch Institute, Washington, DC, United States3Departmentof Pediatrics, The George Washington University School of Medicine and Health, Sciences, Washington, DC, United StatesAbstractBackground–The objective of this study was to assess the value of a urinary biomarker profile comprised of Neutrophil Gelatinase-associated Lipocalin (NGAL), Fibroblast Development Factor-2 (FGF-2), and Epidermal Development Issue (EGF), to detect acute kidney injury (AKI) in critically ill neonates. Methods–We carried out a prospective cohort pilot study of at-risk neonates treated in a level IIIC neonatal intensive care unit (NICU) with therapeutic hypothermia (HT) (n = 25) or extracorporeal membrane oxygenation (ECMO) (n=10). Urine was collected at baseline, 48 hours of illness, and 24 hours post recovery of their corresponding therapies. Control samples have been collected f.
