Barbara C. Fantastic, PhD, for editorial assistance. We also thank the members on the NSABP’s Diversity Strategic Planning Functioning Group for their assistance and efforts in the preparing and execution on the STAR trial. Funding This study was supported by Public Wellness Service grants U10-CA-37377, U10-CA-69974, U10-CA-12027, and U10-CA-69651 from the National Cancer Institute, National Institutes of Overall health, Department of Overall health and Human Services, AstraZeneca, and Eli Lilly.
CLINICAL RESEARCHe-ISSN 1643-3750 ?Med Sci Monit, 2014; 20: 725-732 DOI: 10.12659/MSM.Received: Accepted: Published: 2014.01.23 2014.03.10 2014.05.Impact of high dose vitamin C on Epstein-Barr viral infectionACDE AAuthors’ Contribution: Study Design A Data Collection B Statistical Analysis C Information Interpretation D Manuscript Preparation E Literature Search F Funds Collection GNina A.DBCO-acid web Mikirova Ronald HunninghakeBio-Communication Investigation Institute, Riordan Clinic, Wichita, KS, U.S.A.Corresponding Author: Source of support:Nina A. Mikirova, e-mail: [email protected] Departmental sourcesBackground: Material/Methods:Final results:Conclusions:Numerous natural compounds had been tested for the ability to suppress viral replication. The present manuscript information an evaluation of higher dose vitamin C therapy on patients with EBV infection. The data had been obtained from the patient history database in the Riordan Clinic. Among people in our database who had been treated with intravenous vitamin C (7.five g to 50 g infusions) among 1997 and 2006, 178 patients showed elevated levels of EBV EA IgG (range 25 to 211 AU) and 40 showed elevated levels of EBV VCA IgM (range 25 to 140 AU). The majority of these patients had a diagnosis of chronic fatigue syndrome, together with the rest becoming diagnosed as getting mononucleosis, fatigue, or EBV infection. Our data offer evidence that high dose intravenous vitamin C therapy includes a positive impact on disease duration and reduction of viral antibody levels. Plasma levels of ascorbic acid and vitamin D had been correlated with levels of antibodies to EBV. We discovered an inverse correlation among EBV VCA IgM and vitamin C in plasma in sufferers with mononucleosis and CFS which means that individuals with higher levels of vitamin C tended to possess lower levels of antigens inside the acute state of illness.1523606-23-6 Price Furthermore, a relation was identified amongst vitamin D levels and EBV EA IgG with reduced levels of EBV early antigen IgG for greater levels of vitamin D.PMID:23381601 The clinical study of ascorbic acid and EBV infection showed the reduction in EBV EA IgG and EBV VCA IgM antibody levels more than time in the course of IVC therapy that is certainly consistent with observations from the literature that millimolar levels of ascorbate hinder viral infection and replication in vitro. Administration,Intravenous ethods scorbicAcidDeficiency herapy?Epstein-BarrVirusInfections istory itaminD lood http://medscimonit/download/index/idArt/MeSH Keyword phrases:Full-text PDF:This function is licensed beneath a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported LicenseIndexed in: [Current Contents/Clinical Medicine] [SCI Expanded] [ISI Alerting System] [ISI Journals Master List] [Index Medicus/MEDLINE] [EMBASE/Excerpta Medica] [Chemical Abstracts/CAS] [Index Copernicus]CLINICAL RESEARCHMikirova N.A. et al.: Impact of higher dose vitamin C on Epstein-Barr viral infection ?Med Sci Monit, 2014; 20: 725-BackgroundThe Epstein-Barr virus (EBV) is actually a member in the herpes household that targets lymphocytes and epithelial cells [1?]. It binds to B-lymphocytes by way of the C.
